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Claudiu Supuran

Claudiu T. Supuran


Claudiu T. Supuran is professor of medicinal and pharmaceutical chemistry at the University of Florence, Italy, since 1995. He did his Ph D at University of Bucharest, Romania, and was a visiting scholar at University of Florida, Gainesville, USA, and at Grifitth University, Brisbane, Australia. He was visiting professor at University of La Plata, Argentina and at University of New South Wales, Sydney, Australia. His main research interest is the medicinal chemistry/biochemistry of carbonic anhydrases, field in which he has made contributions to the design of many novel classes of enzyme inhibitors and activators, deciphering their mechanism of action at molecular level, discovery of new isoforms and their role in disease (cancer, obesity, epilepsy, neuropathic pain and cognition), discovery and characterization of carbonic anhydrases from various organisms (bacteria, fungi, corals, vertebrates other than humans and rodents, etc). Other research interests include X-ray crystallography of metallo-enzymes, heterocyclic chemistry, chemistry of sulfonamides, metal-based drugs, cyclooxygenases, serine proteases, matrix metalloproteinases, bacterial proteases, and amino acid derivatives among others. He has published more than 1500 papers in these fields and his Hirsch index is 134. One of the compounds discovered in his laboratory (SLC-0111) is in Phase II clinical trials for the treatment of advanced metastatic solid tumors